Biological Evaluation of 1, 2-bis (2, 4, 6-Trinitrophenyl) Hydrazine

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Biological Evaluation of 1, 2-bis (2, 4, 6-Trinitrophenyl) Hydrazine

Many hydrazine derivatives show remarkable biological activities [1]. Hydrazine derivatives are well known among pesticides, drugs, amino acid precursors, and synthetic building blocks for heterocycle synthesis. Several similar compounds were shown to be effective for treatment of tuberculosis, Parkinson’s disease, and hypertension [2]. Also, hydrazine-based peptidomimetics (azapeptides) are fo...

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Crystals of the title compound, C(10)H(8)N(2)O(2), were obtained from a condensation reaction of hydrazine hydrate with furfural. In the crystal structure, the mol-ecule is centrosymmetric and almost planar and the furan rings are parallel by symmetry.

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The title Schiff base compound, C(14)H(10)Cl(2)N(2), crystallizes with one half-mol-ecule in the asymmetric unit. The mid-point of the N-N bond [1.418 (3) Å] lies on an inversion centre. The mol-ecular skeleton is approximately planar, the largest deviation from the mean plane being 0.143 (4) Å for the N-bonded C atom. The crystal packing exhibits no classical inter-molecular hydrogen bonds.

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The asymmetric unit of the title compound, C(16)H(14)ClN(3)OS, contains two independent mol-ecules (A and B) linked into dimers via N-H⋯N hydrogen bonds. The 1,3-benzothia-zol-2-yl ring system and the benzene ring form dihedral angles of 17.08 (8) and 8.63 (7)° in mol-ecules A and B, respectively.

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ژورنال

عنوان ژورنال: Indian Journal of Pharmaceutical and Biological Research

سال: 2013

ISSN: 2320-9267

DOI: 10.30750/ijpbr.1.4.5